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SOCS-1 polyclonal antibody

 
ALX-210-392-R200 200 µl 210.00 USD
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Product Specification

Alternative Name:JAB, SSI-1, TIP-3, Suppressor of cytokine signaling-1
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 54-68 of human SOCS-1 (suppressor of cytokine signalling-1).
 
UniProt ID:O15524
 
Species reactivity:Human, Mouse
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:500 - 1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:SOCS-1 also known as JAB and (STAT)-induced STAT inhibitor 1 (SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signalling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin. SOCS1/JAB is rapidly induced by LPS and negatively regulates LPS signalling.
 
210-392
Figure: Western blot analysis of SOCS-1 using Prod. No. ALX-210-392 at 1:1000 dilution against 15 mg/lane of Ramos (A) and Raw (B) cell lysate.
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210-392

General Literature References

A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts: S. Ilangumaran, et al.; J. Immunol. 169, 5010 (2002), Abstract;
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation: I. Kinjyo, et al.; Immunity 17, 583 (2002), Abstract;
SOCS proteins: negative regulators of cytokine signaling: D.L. Krebs and D.J. Hilton; Stem Cells 19, 378 (2001), Abstract;

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