Toll-like receptor 3 (mouse), pAb



ALX-210-367-R200	200 µl	304.00 USD

Product Specification

Alternative Name:	TLR3, CD283

Concentration:	0.5mg/ml

Purity Detail:	Protein G-affinity purified.

Formulation:	Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.

Immunogen:	Synthetic peptides corresponding to aa 135-150, 828-844 and 876-891 of mouse TLR3 (Toll-like receptor 3).

Source/Host:	From rabbit.

Specificity:	Recognizes mouse TLR3. Does not cross-react with human TLR3.

Application:	Flow Cytometry (cell surface & intracellular (1μg/10⁶cells)) Immunohistochemistry (paraffin sections (1:50), frozen sections) Western Blot (1-3µg/ml)

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Stable for 6 months when stored at +4°C.

Handling:	Avoid freeze/thaw cycles.

Positive Control:	Mouse spleen cell whole cell lysate can be used as positive control.

Background / Technical Information:	Replacement for ADI-CSA-790

Figure 1: Western blot analysis of TLR3 in 15µg/lane mouse spleen tissue lysate using PAb to Toll-like Receptor 3 (mouse) (Prod. No. ALX-210-367).

Figure 2: Intracellular flow analysis of TLR3 in Balb/c mouse splenocytes using PAb to Toll-like Receptor 3 (mouse) (Prod. No. ALX-210-367) at 1μg/10⁶ cells. Shaded histogram represents cells without antibody; green represents rabbit IgG isotype control; red represents PAb to Toll-like Receptor 3 (mouse).

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Product Literature References

Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice: P.S. Patole, et al.; Nephrol. Dial. Transplant. 21, 3062 (2006), Abstract;

Toll-like receptor-7 modulates immune complex glomerulonephritis: R.D. Pawar, et al.; J. Am. Soc. Nephrol. 17, 141 (2006), Abstract;

Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells: P.S. Patole, et al.; J. Am. Soc. Nephrol. 16, 1326 (2005), Abstract;