ANGPTL4 (rat), pAb



ALX-210-360-C100	100 µg	358.00 USD

Product Specification

Alternative Name:	FIAF, Fasting-induced adipose factor, HFARP, Angiopoietin-like protein 4, Hepatic fibrinogen/angiopoietin-related protein, PGAR

Concentration:	1mg/ml

Purity Detail:	Epitope-affinity purified.

Formulation:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.

Immunogen:	Synthetic peptide corresponding to aa 80-94 (C⁸⁰QGPKGKDAPFKDSE⁹⁴) of mouse ANGPTL4 (angiopoietin-like protein 4).

Source/Host:	From rabbit.

Specificity:	Recognizes rat ANGPTL4. Detects a band of ~50kDa by Western blot.

Application:	Western Blot (2µg/ml)

Long Term Storage:	-20°C

Handling:	Avoid freeze/thaw cycles.

Blocking Peptide:	For Blocking Peptide see Prod. No. ALX-156-004.

Miscellaneous/General:	Adipose tissue is an energy reserve in animals and, in nondomestic species, is strictly regulated. Adipose cells produce and secrete numerous physiologically important proteins that help regulate whole body metabolism, such as leptin and adiponectin. Fasting causes significant changes in nutrient metabolism and many of these changes are controlled by transcription factors that regulate rate-limiting enzymes. An important transcription factor that mediates metabolic processes induced by fasting is peroxisome proliferator-activated receptor α (PPARα). PPARα has been reported to target a gene encoding the secreted protein ANGPTL4 (angiopoietin-like protein 4; FIAF; fasting-induced adipose factor). ANGPTL4 is expressed predominantly in adipose tissue and is strongly upregulated in white adipose tissue and the liver under fasting conditions. Initial studies suggest that ANGPTL4 represents an endocrine signal helping to regulate metabolism, especially under fasting conditions.

Figure: Western blot on ANGPTL4 in rat adipose tissue extract using PAb to ANGPTL4 (rat) (Prod. No. ALX-210-360).

Please mouse over

Product Literature References

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene: S. Kersten, et al.; J. Biol. Chem. 275, 28488 (2000), Abstract; Full Text