Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Osteopontin polyclonal antibody

 
ALX-210-309-R020 20 µl 205.00 USD
 
ALX-210-309-R100 100 µl 809.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:Bone sialoprotein 1, Secreted phosphoprotein 1, OPN, SPP1
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 59-74 (P59SKSNESHDHMDDMDD74) of mature human osteopontin.
 
UniProt ID:P10451
 
Gene/Protein Identifier:6696 (Entrez GeneID)
 
Species reactivity:Human, Mouse
 
Crossreactivity:Does not cross-react with human osteonectin or bone sialoprotein.
 
Applications:ELISA, IHC (PS), WB
 
Recommended Dilutions/Conditions:ELISA (1:1,000)
Immunohistochemistry (paraffin sections, 1:100-1:1500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Lyophilized. From neat/unpurified rabbit serum.
 
Reconstitution:Reconstitute with 20µl or 100µl distilled water.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.
 
ALX-210-309 IHC
Immunohistochemistry analysis of fetal calvaria (paraffin section) stained with Osteopontin, pAb (Prod. no. ALX-210-309) at 1:1500.
Please mouse over
ALX-210-309 IHC

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Osteopontin
By biological activity:
Osteopontin Polyclonal antibody
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,