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SNAP-25 polyclonal antibody

 
ALX-210-279-R100 100 µl 437.00 USD
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Product Specification

Alternative Name:Synaptosomal-associated protein 25
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 195-206 (A195NQRATKML
GSG206) of rat SNAP-25 (synaptosomal-associated protein 25).
 
UniProt ID:P60881
 
Species reactivity:Mouse, Rat
Bovine, Zebrafish
 
Applications:ICC, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:100)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~25kDa by Western blot.
 
Purity Detail:Epitope-affinity purified IgG.
 
Formulation:Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:SNAP-25 (synaptosomal associated protein of 25kDa) is a soluble protein of 25kDa which plays a key role in vesicle membrane fusion events with the plasma membrane. This protein was originally discovered to be enriched in subsets of neurons in the brain and displays a presynaptic pattern of expression. The membrane proteins SNAP-25, synaptobrevin, and syntaxin form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins NSF and α-SNAP. Functional interactions have been demonstrated to exist between SNAP-25, syntaxin, and the synaptic protein interaction site on voltage-sensitive L- and N-type Ca2+ channels. SNAP-25 has been shown to be required for synaptic vesicle fusion with the plasma membrane during release of NGF. Regulated exocytosis of cortical granule secretion in fertilized eggs and membrane fusion events in neurons and endocrine cells is mediated by SNAP-25 in a Ca2+-dependent mechanism. SNAP-25 protein levels have been shown to be elevated in prolactinoma and GH/PRL tumor cells while reduced SNAP-25 protein expression has been observed between schizophrenic and normal hippocampal cells. Altered patterns of SNAP-25 expression have also been observed in the inferior temporal cortex and prefrontal association cortex between normal brains and brains from individuals affected with schizophrenia. SNAP-25 accumulation due to cytoskeletal dysfunction is also observed in the swollen axons of the white matter of individuals with severe Alzheimer's dementia.
 
210-279
Figure: Immunocytochemistry of SNAP-25 in cultured rat hippocampal cells using PAb to SNAP-25 (Prod. No. ALX-210-279).
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210-279

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