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Munc-18 polyclonal antibody

 
ALX-210-247-C100 100 µg 419.00 USD
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Product Specification

Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 58-70 (V58EDINKRREPIPS70) of human Munc-18.
 
UniProt ID:P61764 (Munc-18-1), Q15833 (Munc-18-2)
 
Species reactivity:Mouse, Rat
 
Applications:IHC (FS), IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml)
 
Application Notes:Detects a band of ~67kDa by Western blot.
 
Purity Detail:Epitope-affinity purified IgG.
 
Formulation:Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Munc-18 is a cytosolic brain protein of ~67kDa which plays a key role in vesicle membrane fusion events with the plasma membrane. Functional interactions have been demonstrated to exist between Munc-18, SNAP-25, synaptobrevin, and syntaxin. Munc-18 is the mammalian homologue of the C. elegans gene unc-18. Mutations in unc-18 can result in accumulations of acetylcholine and paralytic phenotype suggestive of a neurotransmitter release defect. Munc-18 thus appears to be required by the synaptic vesicle fusion complex. Two Munc-18 isoforms have been identified. Munc-18-1 has been shown to be primarily expressed in brain, while Munc-18-2 is expressed in most tissues.
 
210-247
Figure 1: Western blot of Munc-18 in rat brain homogenate immunoprecipitated with Munc-18, pAb (Prod. No. ALX-210-247).
Lane 1: Extract only.
Lanes: 2-4. 750µg of extract immunoprecipitated with 1µg, 5µg, and 10µg of ALX-210-247, respectively.
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210-247

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