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Early endosomal antigen 1 polyclonal antibody

 
ALX-210-239-C100 100 µg 562.00 USD
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Replaces Prod. #: ALX-210-239/1

Product Specification

Alternative Name:EEA1
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 1391-1410 (T1391PSSKKPVR
VCDACFNDLQG1410) of human EEA1 (early endosomal antigen 1).
 
UniProt ID:Q15075
 
Species reactivity:Mouse
 
Applications:WB
 
Application Notes:Detects a band of ~160kDa by Western blot.
 
Purity Detail:Epitope-affinity purified IgG.
 
Formulation:Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:EEA1 is a 162kDa membrane bound protein component specific to the early endosome and is essential for fusion between early endocytic vesicles. Early endosomes are cytoplasmic compartments which fuse with endocytic vesicles for redistribution of extracellular compounds to alternate destinations. Zinc-finger-like domains reminiscent of those found in nucleic acid binding proteins are located in the amino and carboxyl-terminal domains of EEA1. The COOH-terminal zinc-finger-like-domain is conserved in several other non-nuclear proteins, some of which are also involved in intracellular protein trafficking. In addition, this domain is an authentic zinc-binding domain and is critical to the intracellular localization of EEA1. Membrane association of EEA1 has been shown to be dependent on phosphatidyl 3-kinase activity, inhibitors of which cause EEA1 to dissociate from early endosomes.
 

Product Literature References

Severe hypochromic microcytic anemia caused by a congenital defect of the iron transport pathway in erythroid cells: M. Priwitzerova, et al.; Blood 103, 3991 (2004), Abstract;

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