Cyclophilin B, pAb - Enzo Life Sciences

ALX-210-237/1

Revised 01-Feb-10

Cyclophilin B, pAb
SYNONYMS	CyPB
PRODUCT LINE	Immunology
PRODUCT CATEGORY	Immunophilins / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-237/1-C100		100 µg	531.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat Dog
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml.
PURITY DETAIL:	Epitope-affinity purified IgG.
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 194-208 (C¹⁹⁴GKIEVEKPFAIAKE²⁰⁸) of human cyclophilin B.
SPECIFICITY:	Recognizes human, mouse, rat and dog cyclophilin B. Detects a band of ~19kDa by Western blot.
APPLICATION:	Western Blot (0.5µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-153-028.

General Information

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) (see Prod. No. ALX-380-002) or FK506 (see Prod. No. ALX-380-008). Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.

General Literature References

Transport activity and surface expression of the Na+-Ca2+ exchanger NCX1 are inhibited by the immunosuppressive agent cyclosporin A and by the nonimmunosuppressive agent PSC833: C. Kimchi-Sarfaty, et al.; J. Biol. Chem. 277, 2505 (2002) Abstract; Full Text

Further Categories Containing This Product:

Polyclonal Antibodies