FKBP51, pAb - Enzo Life Sciences

ALX-210-236

Revised 01-Feb-10

FKBP51, pAb
SYNONYMS	FK506 binding protein (51kDa)
PRODUCT LINE	Immunology
PRODUCT CATEGORY	Immunophilins / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-236-C100		100 µg	531.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat Dog Others
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Epitope affinity-purified IgG.
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 394-407 (C³⁹⁴QKKAKEHNERDRR⁴⁰⁷) of human FKBP51 (FK506 binding protein 51).
SPECIFICITY:	Recognizes human, mouse, rat, hamster and dog FKBP51. Detects a band of ~51kDa by Western blot.
APPLICATION:	Western Blot (1:1'000).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-156-003.

Product Description

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) (Prod. No. ALX-380-002) or FK506 (Prod. No. ALX-380-008). Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP’s) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase’s, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Prod. No. ALX-210-236 is a polyclonal antibody that reacts with a ~51kDa protein which is found associated with the progesterone receptor. This protein is also referred to as FKBP54 and FKBP5 in the literature. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids.

Further Categories Containing This Product:

Polyclonal Antibodies