FKBP51, pAb

[FK506 binding protein (51kDa)]



ALX-210-236-C100	100 µg	531.00 USD

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) (Prod. No. ALX-380-002) or FK506 (Prod. No. ALX-380-008). Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP’s) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506.

Concentration:	1mg/ml

Purity Detail:	Epitope affinity-purified IgG.

Formulation:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.

Immunogen:	Synthetic peptide corresponding to aa 394-407 (C³⁹⁴QKKAKEHNERDRR⁴⁰⁷) of human FKBP51 (FK506 binding protein 51).

Source/Host:	From rabbit.

Specificity:	Recognizes human, mouse, rat, hamster and dog FKBP51. Detects a band of ~51kDa by Western blot.

Application:	Western Blot (1:1'000).

Shipping:	SHIPPED ON BLUE ICE

Long Term Storage:	-20°C

Handling:	Avoid freeze/thaw cycles.