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Myosin VIIa (mouse) polyclonal antibody

ALX-210-227-R200 200 µl 457.00 USD
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Product Specification

Immunogen:Synthetic peptide corresponding to aa 16-31 (S16GQEFDVPIGA
VVKLC31) of the N-terminal motor domain of mouse myosin. This sequence is completely conserved in human and pig myosin VIIa.
UniProt ID:P97479
Species reactivity:Mouse
Specificity:The antibody recognizes myosin VIIa from mouse tissues as well as recombinant protein. It has been successfully used in Western blot procedures in which it detects an ~220 kDa protein representing myosin VIIa from mouse testes preparations. It detects recombinant mouse myosin VIIa overexpressed in Sf9 insect cell lysate.
Recommended Dilutions/Conditions:Western Blot (1:200)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~220kDa by Western blot.
Purity Detail:Epitope-affinity purified IgG.
Formulation:Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Myosin VIIa is a member of the myosin superfamily of actin-based motor proteins, containing an ATP-binding N-terminal motor domain, a central region which possesses five light-chain binding (IQ) motifs, and a C-terminal domain with three myosin tail homology (myTH4) and talin-like homology regions. Defects in the myosin VIIa gene are responsible for hearing impairment in shaker-1 (sh1) mice and causes Usher syndrome IB in humans.
Usher syndrome associates congenital deafness, vestibular dysfunction, and retinitis pigmentosa and is the most common form of combined deafness and blindness.
Structural features of myosin VIIa protein include an ATP binding N-terminal motor domain, a central region which possess five light-chain binding (IQ) motifs, and a C-terminal domain with three myosin tail homology (MyTH4) and talin-like homology regions.

Figure: Western blot of myosin VIIa in mouse testes tissue extract using PAb to Myosin VIIa (mouse) (Prod. No. ALX-210-227).

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