Peroxisomal membrane protein 70 (mouse), pAb

Alternative Name:	ABCD3, PMP70

Concentration:	1mg/ml.

Purity Detail:	Epitope-affinity purified IgG.

Formulation:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.

Immunogen:	Synthetic peptide corresponding to aa 644-659 (CN⁶⁴⁴YEFKKITED TVEFGS⁶⁵⁹) of C-terminal rat PMP70 (peroxisomal membrane protein 70). This sequence is completely conserved in mouse PMP70 and differs from human PMP70 by a single aa substitution.

Source/Host:	From rabbit.

Specificity:	Recognizes mouse PMP70. Detects a band of ~70kDa by Western blot.

Application:	Flow Cytometry Western Blot (1:500)

Long Term Storage:	-20°C

Handling:	Avoid freeze/thaw cycles.

Miscellaneous/General:	Peroxisomes are single membrane organelles which are involved in many important biochemical pathways and are found in almost all eukaryotic cells. Various toxins including phenols, alcohols, and aldehydes are targeted for modification by peroxisomes. Long chain fatty acid metabolism via β-oxidation is also mediated by this organelle. Loss of peroxisomal functions may result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsums disease. Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome. This protein is induced by treatment with hypolipidemic agents in parallel with peroxisome proliferation and stimulation of the peroxisomal β-oxidation enzymes.