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NEDD8 polyclonal antibody

ALX-210-194-R200 200 µl Inquire for pricing
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Product Specification

Immunogen:Synthetic peptide corresponding to aa 20-32 (T20DKVERIKERVEE32) of human NEDD8.
UniProt ID:Q15843
Species reactivity:Human, Mouse, Rat
Crossreactivity:Does not cross-react with ubiquitin or SUMO.
Applications:ICC, IHC, IP, WB
Recommended Dilutions/Conditions:Immunocytochemistry (1:500)
Western Blot (1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Formulation:Liquid. Contains 50% glycerol and 1mM sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C

Product Literature References

Itch promotes the neddylation of JunB and regulates JunB-dependent transcription: H. Li, et al. ; Cell. Signal. 28, 1186 (2016), Application(s): Immunoblotting, Abstract;
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis: P. Xie, et al.; Nat. Commun. 5, 3733 (2014), Application(s): Western blot, Abstract;
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes: R. Hjerpe, et al.; Biochem. J. 441, 927 (2012), Application(s): Western blot, Abstract; Full Text
The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe: D. Girdwood, et al.; PLoS One 6, e20089 (2011), Application(s): Western blot, Abstract; Full Text
Hypoxia-inducible factors in the first trimester human lung: F. Groenman, et al.; J. Histochem. Cytochem. 55, 355 (2007), Abstract;
The COP9 signalosome regulates Skp2 levels and proliferation of human cells: S. Denti, et al.; J. Biol. Chem. 281, 32188 (2006), Application(s): Western blot, Abstract; Full Text
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity: D.P. Xirodimas, et al.; Cell 118, 83 (2004), Abstract;
Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1): M. Morimoto, et al.; BBRC 270, 1093 (2000), Abstract;
Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha: M.A. Read, et al.; Mol. Cell Biol. 20, 2326 (2000), Abstract;
Cleavage of the C-terminus of NEDD8 by UCH-L3: H. Wada, et al.; BBRC 251, 688 (1998), Abstract;
Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein: T. Kamitani et al.; J. Biol. Chem. 272, 28557 (1997), Abstract; Full Text

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