Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Ca2+-sensing receptor polyclonal antibody

 
ALX-210-143-R100 100 µl 562.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-210-143/1

Product Specification

Alternative Name:CASR
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 12-27 (A12LAWHSSAYGPDQRAQ27) of rat CASR (Ca2+-sensing receptor).
 
UniProt ID:P48442
 
Species reactivity:Human, Rat
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:100)
 
Application Notes:Detects a band of ~120kDa by Western blot.
 
Purity Detail:Epitope-affinity purified.
 
Formulation:Liquid. In PBS containing 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The calcium sensing receptor (CASR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Based on sequence analysis of cDNA clones it appears that the CASR is similar to the 7-transmembrane-domain G-protein-coupled receptor superfamily. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CASR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).
 

Product Literature References

Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium: S.E. McNeil, et al.; J. Biol. Chem. 273, 1114 (1998), Abstract; Full Text

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Calcium sensing receptor
By biological activity:
Calcium sensing receptor Polyclonal antibody
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,