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Furin convertase polyclonal antibody

 
ALX-210-134-R100 100 µl 604.00 USD
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Product Specification

Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 780-793 (R780GERTAFIKDQSAL793) of C-terminal human furin.
 
UniProt ID:P09958
 
Species reactivity:Mouse
Dog
 
Specificity:Recognizes mouse and dog furin convertase and overexpressed human furin convertase. Does not detect endogenous furin from BSC-40, HeLa, J774A-1 BPAEC or CHO cells.
 
Crossreactivity:Does not cross-react with rat furin convertase.
 
Applications:ICC, IF, IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:100)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Immunocytochemical staining of endogenous furin convertase in 3T3 cells with Prod. No. ALX-210-134 yields a pattern consistent with paranuclear staining.
Detects a band of ~100kDa by Western blot.
 
Purity Detail:Epitope-affinity purified IgG.
 
Formulation:Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
210-134
Figure: Immunolocalization of endogenous furin in mouse 3T3 cells using PAb to Furin Convertase (Prod. No. ALX-210-134).
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210-134

Product Literature References

Shedding of membrane type matrix metalloproteinase 5 by a furin-type convertase: a potential mechanism for down-regulation: X. Wang & D. Pei; J. Biol. Chem. 276, 35953 (2001), Abstract; Full Text
Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway: G. Liu, et al.; J. Cell Biol. 139, 1719 (1997), Abstract; Full Text

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