BAG-1 (mouse) (CT), pAb (Bur 1702)



ALX-210-009-R050	50 µl	124.00 USD

Product Specification

Alternative Name:	Bcl-2 associated athanogene-1, BAG family molecular chaperone regulator 1, RAP46

Formulation:	Liquid. In PBS containing 0.05% sodium azide.

Immunogen:	Synthetic peptide corresponding to aa 204-219 (C²⁰⁴QETERLQSTNLALAE²¹⁹) of mouse BAG-1 (Bcl-2 associated athanogene-1).

Source/Host:	From rabbit.

Specificity:	Recognizes mouse BAG-1.

Application:	Immunohistochemistry (paraffin sections (1:2'500)) Immunoprecipitation (transfected cells) Western Blot (1:500-1:1'000)

Long Term Storage:	-80°C

Use/Stability:	Stable for at least 1 year after receipt when stored at -80°C.

Handling:	Avoid freeze/thaw cycles.

Miscellaneous/General:	BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-1 functions as a nucleotide exchange factor of mammalian cytosolic HSC70, thereby triggering substrate unloading from the chaperone. In addition BAG-1 associates with the proteasome, playing a role in coordinating chaperone and degradation pathways. Aberrant BAG-1 expression has been observed in certain human cancers.

Product Literature References

Bag1 is a regulator and marker of neuronal differentiation: P. Kermer, et al.; Cell Death Differ. 9, 405 (2002), Abstract;

Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2: C.V. Clevenger, et al.; Mol. Endocrinol. 11, 608 (1997), Abstract; Full Text

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1: H.G. Wang, et al.; PNAS 93, 7063 (1996), Abstract; Full Text

Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain: M. Adachi, et al.; Blood 88, 4118 (1996), Abstract; Full Text

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity: S. Takayama, et al.; Cell 80, 279 (1995), Abstract;

General Literature References

BAG-1: a multi-functional pro-survival molecule: P.A. Townsend, et al.; Int. J. Biochem. Cell. Biol. 37, 251 (2005), Abstract;

BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions: S. Alberti, et al.; Cell Stress Chaperones 8, 225 (2003), Abstract; Full Text