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ACRP30headless (human), (recombinant)

 
ALX-203-002-C010 10 µg 275.00 USD
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Control compound. When used at 1µg/g body weight in mouse demonstrated no significant bioactivity in terms of reduction of serum glucose compared to wildtype in an in vivo assay.

Product Specification

Alternative Name:Adipocyte complement related protein of 30kDa headless, Tail-Adp, Tail Adiponectin
 
MW:~27kDa
 
Source:Produced in HEK 293 cells. The non-homologous (aa 16-45) and collagen domain of human ACRP30 (aa 45-108) are fused at the N-terminus to a FLAG®-tag.
 
UniProt ID:Q15848
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥90% (SDS-PAGE)
 
Purity Detail:Purified by multi-step chromatography.
 
Endotoxin Content:<0.1EU/µg protein (LAL-test).
 
Application Notes:Negative control. When used at 1µg/g body weight in mouse demonstrated no significant bioactivity in terms of reduction of serum glucose compared to wildtype in an in vivo assay.
 
Reconstitution:Reconstitute with 100µl sterile water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored as recommended.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Technical Info/Product Notes:FLAG is a registered trademark of Sigma-Aldrich Co.
 
203-002
Figure 1: Bioactivity of rmsAdiponectin.Method: 2 groups of 4 mice each were injected with PBS (vehicle), rmAdiponectin (Prod. No. ALX-522-059) and rhACRP30headless (tail adiponectin) (Prod. No. ALX-203-002) at 1µg/g body weight as a tail vein injection. Subsequently, serum glucose levels were monitored over the time indicated by Trinder assay. Plotted is the average of 4 mice. rmAdiponectin represses hepatic glucose production, so serum glucose levels decrease until counter-regulatory mechanisms (i.e. glucagon) become effective. rhACRP30headless demonstrated no significant bioactivity in terms of reduction of serum glucose compared to wildtype in this in vivo assay.
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203-002

Product Literature References

Adiponectin acts in the brain to decrease body weight: Y. Qi, et al.; Nat. Med. 10, 524 (2004), Abstract;
Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: Implications for metabolic regulation and bioactivity: U.B. Pajvani, et al.; J. Biol. Chem. 278, 9073 (2003), Abstract; Full Text

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