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Myelin basic protein (bovine brain), (high purity)

 
ALX-202-076-M005 5 mg 175.00 USD
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Replaces Prod. #: BML-SE458

Substrate for various kinases including MAPK, PKA, calmodulin-dependent protein kinase, PKC and phosphorylase kinase. Raf1, MEK, and MEKK can also use MBP as a substrate.

Product Specification

Alternative Name:MBP
 
Source:Purified from bovine central nervous system tissue by method of Määttä et al..
 
UniProt ID:P02687
 
Formulation:Lyophilized. Essentially salt-free.
 
Purity:≥95% (SDS-PAGE; immunoblot)
 
Reconstitution:Reconstitute with distilled water.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year when stored at +4°C. Reconstituted protein is stable for at least 6 months at -20°C and for at least 24 hours at +37°C in aqueous solution.
 
Scientific Background:MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca2+-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley.MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C, calmodulin-dependnet protein kinase, phosphoryl kinase). Raf1, MEK and MEKK can also use MBP as a substrate. MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.
 

Product Literature References

Could Intrathymic Injection of Myelin Basic Protein Suppress Inflammatory Response After Co-culture of T Lymphocytes and BV-2 Microglia Cells?: Z.Q. Cui, et al.; Chin. Med. J. (Engl.) 129, 831 (2016), Application(s): Injection into mice, Abstract; Full Text
Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997), Abstract;

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