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ST2 (human), (recombinant) (His-tag)

ALX-201-767-0050 50 µg 325.00 USD
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Product Specification

Alternative Name:IL1RL1, Interleukin-1 receptor-like 1, Interleukin-33 receptor
Source:Produced in E.coli. It is a single, non-glycosylated, polypeptide chain containing 310 amino acids fragment (19-328) corresponding to the soluble IL1RL1 coding sequence, and fused with a 4.5kDa amino-terminal hexahistidine tag.
UniProt ID:Q01638
Formulation:Liquid. In sterile-filtered 25mM sodium acetate, pH 4.8, containing 50% glycerol.
Purity:≥95% (SDS-PAGE)
Purity Detail:Purified by proprietary chromatographic techniques.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Working aliquots are stable for up to 3 months when stored at -20°C.
Handling:For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Scientific Background:The ST2 gene is a member of the IL-1 receptor family, encoding a transmembrane protein with a structure similar to IL-1R1. ST2 is a receptor for interleukin-33, its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. ST2 may possibly be involved in helper T-cell function. ST2 is highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine.
A soluble form of the ST2 is produced from the same gene by alternative splicing and was shown to be expressed in several cell types including fibroblasts and mast cells. Soluble ST2 also acts as a negative regulator of Th2 cytokine production and high levels have been reported in several disease states and conditions including asthma, sepsis and myocardial infarction.
Analysis of the similar gene in mouse suggested that the IL1RL1 receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells.

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For Research Use Only. Not for use in diagnostic procedures.
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