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DLL4 (soluble) (human), (recombinant)

Notch ligand
 
ALX-201-766-0025 25 µg 342.00 USD
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Product Specification

Alternative Name:Delta-like protein 4, Delta4
 
MW:~54kDa
 
Source:Produced in HEK 293 cells. Recombinant human sDLL-4 contains 498 amino-acid residues.
 
UniProt ID:Q9NR61
 
GenBank ID:54567
 
Formulation:Lyophilized.
 
Purity:≥95% (SDS-PAGE and HPLC)
 
Endotoxin Content:< 0.1 ng per μg of sDLL-4.
 
Biological Activity:The sDLL-4, when immobilized at concentrations >1.5 μg/mL will inhibit myogenesis in C2C12 cells.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted sDLL-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Scientific Background: Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors.
 

General Literature References

Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting: I.B. Lobov, et al.; PNAS 104, 3219 (2007), Abstract;
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis: M. Hellstrom, et al.; Nature 445, 776 (2007), Abstract;
Dll4, a novel Notch ligand expressed in arterial endothelium: J.R. Shutter, et al.; Genes Dev. 14, 1313 (2000), Abstract;
Human ligands of the Notch receptor: G.E. Gray, et al.; Am. J. Pathol. 154, 785 (1999), Abstract; Full Text

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