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Matriptase-2 (human), (recombinant)

Integral player in iron homeostasis, acts as a potent negative regulator of hepcidin.
 
ALX-201-752-1 125 U 344.00 USD
 
ALX-201-752-0500 500 U 435.00 USD
Do you need bulk/larger quantities?
 
  • Highly active serine protease providing superior results.
  • Potent negative regulator of hepcidin.
  • Eukaryotic cell-derived protein guarantees proper PTM.

Product Specification

Alternative Name:Transmembrane protease serine 6, TMPRSS6
 
MW:~84kDa; a-subunit: ~56kDa; b-subunit: ~28kDa
 
Source:Produced in Drosophila Schneider 2 (S2) cells. Recombinant human matriptase-2 (aa 78-811) is fused at the C-terminus to a V5-His-tag.
 
EC:3.4.21.109
 
UniProt ID:Q8IU80
 
Formulation:Liquid. In 100mM TRIS-HCl, pH 9.0, containing 150 mM sodium chloride and 20% glycerol.
 
Purity Detail:Purified by multi-step chromatography.
 
Activity:≥2.5 U/µl
Please see Certificate of Analysis for detailed activity information.
 
Biological Activity:Trypsin-like serine protease.
 
Specific Activity:One U = 10 pmol/min, using Boc-Gln-Ala-Arg-AMC (50µM, Prod. No. BML-P237) as substrate at 37°C.
 
Shipping:Shipped on Dry Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-80°C
 
Use/Stability:Stable for at least 6 months when stored at -20°C. Recommended Assay Buffer: 100mM TRIS, pH 9.0, containing 0.5mg/ml BSA. Do not store diluted solutions.
 
Handling:Avoid freeze/thaw cycles.
 
Scientific Background:Matriptase-2 (TMPRSS6) is a type II transmembrane serine protease mainly produced by the liver. It acts as a potent negative regulator of hepcidin, a hepatic peptide hormone and integral player in regulating iron homeostasis.

Matriptase-2 plays an important role in understanding iron disorders; including various anemias and iron overload conditions, affecting millions of people worldwide.
 

Product Literature References

A New Method to Assay Protease Based on Amyloid Misfolding: Application to Prostate Cancer Diagnosis Using a Panel of Proteases Biomarkers: H. Li, et al.; Theranostics 4, 701 (2014), Application(s): Assay, Abstract; Full Text
Identification of the first low-molecular-weight inhibitors of matriptase-2: M.T. Sisay, et al.; J. Med. Chem. 53, 5523 (2010), Abstract;
Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides: F. Beliveau, et al.; FEBS J. 276, 2213 (2009), Abstract;

General Literature References

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression: J.E. Maxson, et al.; J. Biol. Chem. 285, 39021 (2010), Abstract;
Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis: A.R. Folgueras, et al.; Blood 112, 2539 (2008), Abstract;
Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients: C. Parr, et al.; Clin. Cancer Res. 13, 3568 (2007), Abstract;

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