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IL-33 (human) (homeodomain-like helix-turn-helix), (recombinant) (His-tag)

ALX-201-468-C010 10 µg 451.00 USD
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Product Specification

Alternative Name:Interleukin-33, NF-HEV, IL-1F11
Source:Produced in E. coli. The homeodomain of human IL-33 (aa 1-111) is fused at the C-terminus to a His-tag.
UniProt ID:O95760
Formulation:Liquid. 0.2µm-filtered solution in 55mM TRIS-HCl, pH 8.2, containing 150mM sodium chloride.
Purity:≥95% (SDS-PAGE)
Purity Detail:His-tag (Ni-NTA) and anion exchange chromatography purified.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Working aliquots are stable for up to 3 months when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Scientific Background:IL-33 gene was initially designated as NF-HEV which encodes a predicted 270-residue protein. The calculated 30 KDa human IL33 is converted by CASP1 to a mature 18-KD
protein. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK.
Nuclear localization, heterochromatinassociation, and targeting to mitotic chromosomes were all found to be mediated by an evolutionarily conserved homeodomain-like helix-turn-helix motif within the IL-33 N-terminal part. IL-33 was found to possess transcriptional repressor properties, associated with the homeodomain-like helix-turn-helix motif.
Figure: SDS-PAGE of IL-33 (human) (homeodomain-like helix-turn-helix), (recombinant) (His) (Prod. No. ALX-201-468).
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Product Literature References

ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis: J.M. Rizzo, et al.; Cell Death Differ. 23, 1073 (2016), Application(s): Immunofluorescence, Abstract;

General Literature References

IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo: V. Carriere et al.; Proc. Natl. Acad. Sci. USA 104, 282 (2007), Abstract;
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005), Abstract;
Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules: E.S. Baekkevold, et al. ; Am. J. Pathol. 163, 69 (2003), Abstract;

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