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βKlotho (extracellular domain) (human):Fc (human), (recombinant)

ALX-201-434-C010 10 µg 502.00 USD
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Product Specification

Alternative Name:Klotho beta-like protein, BKL, KLB
Source:Produced in HEK 293 cells. The extracellular domain of human βKlotho (aa 1-996) is fused at the C-terminus to the Fc portion of human IgG.
UniProt ID:Q86Z14
Formulation:Liquid. 0.2μm-filtered solution in PBS.
Purity:≥90% (SDS-PAGE)
Endotoxin Content:<0.1EU/µg protein (LAL test).
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Working aliquots are stable for up to 3 months when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
201-434 new 04
Figure: SDS-PAGE of βKlotho (extracellular domain) (human):Fc (human) (rec.) (Prod. No. ALX-201-434).
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General Literature References

BetaKlotho is required for metabolic activity of fibroblast growth factor 21: Y. Ogawa, et al.; PNAS 104, 7432 (2007), Abstract; Full Text
Co-receptor requirements for fibroblast growth factor-19 signaling: X. Wu, et al.; J. Biol. Chem. 282, 29069 (2007), Abstract; Full Text
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21: H. Kurosu, et al.; J. Biol. Chem. 282, 26687 (2007), Abstract; Full Text

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