ANGPTL4 (intact form) (rat), (recombinant) (His-tag)



ALX-201-432-C010	10 µg	802.00 USD

Product Specification

Alternative Name:	Angiopoietin-like protein 4, FIAF, Fasting-induced adipose factor, HFARP, Hepatic fibrinogen/angiopoietin-related protein

Endotoxin Content:	<0.1EU/µg protein (LAL-test).

Purity:	≥90% (SDS-PAGE)

Formulation:	Liquid. 0.2μm-filtered solution in PBS.

Source/Host:	Produced in CHO cells. The signal peptide and the mature peptide of rat ANGPTL4 (aa 1-405) are fused at the C-terminus to a His-tag.

Long Term Storage:	-20°C

Use/Stability:	Working aliquots are stable for up to 3 months when stored at -20°C.

Handling:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Background / Technical Information:	UniProt ID Q6TMA8: ANGPTL4 (rat)

Figure 1: SDS-PAGE of ANGPTL4 (Intact Form) (rat) (rec.) (His) (Prod. No. ALX-201-432).

Figure 2: ERK phosphorylation is induced by ANGPTL4 (Intact Form) (rat) (rec.) (His) (Prod. No. ALX-201-432) in THP-1 cells.Method: THP-1 monocyte cells were serum starved for 16h and then stimulated with ANGPTL4 (rat) (rec.) (His) (500ng/ml) for 1, 2 and 3h, respectively. The cell lysates were subjected to do immunoblotting with antibodies against pERK1/2 or total ERK1/2.

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General Literature References

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice: A. Xu, et al.; PNAS 102, 6086 (2005), Abstract; Full Text

Angiopoietin-like-4 is a potential angiogenic mediator in arthritis: L.M. Hermann, et al.; Clin. Immunol. 115, 93 (2005), Abstract;

Genes that mediate breast cancer metastasis to lung: A.J. Minn, et al.; Nature 436, 518 (2005), Abstract; Full Text

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene: S. Kersten, et al.; J. Biol. Chem. 275, 28488 (2000), Abstract; Full Text

Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation: J.C. Yoon, et al.; Mol. Cell Biol. 20, 5342 (2000), Abstract; Full Text