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ANGPTL7 (fibrinogen-like domain) (human), (recombinant)

 
ALX-201-395-C010 10 µg 284.00 USD
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Product Specification

Alternative Name:Angiopoietin-like protein 7, Cornea-derived transcript 6 protein
 
Source:Produced in HEK 293 cells. Fibrinogen-like domain of human ANGPTL7 (angiopoietin-like protein 7) (aa 126-346) is fused at the N-terminus to a FLAG®-tag.
 
UniProt ID:O43827
 
Concentration:~0.5mg/ml
 
Formulation:Liquid. 0.2µm-filtered solution in PBS.
 
Purity:≥90% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg protein (LAL-test).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Working aliquots are stable for up to 3 months when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Scientific Background:Human ANGPTL7 is produced as a secreted glycoprotein. Human mRNA is expressed in neural tissues, keratoconus cornea, trabecular meshwork, melanotic melanoma and uterus endometrial cancer, while mouse Angptl7 mRNA is expressed in four-cell embryos, synovial fibroblasts, thymus, uterus and testis. ANGPTL7 reduces tumor growth and aberrant blood vessel formation by inducing massive fibrosis in a mouse xenograft model. It was reported that addition of ANGPTL7 results in a further increase in HSC activities. This suggests that ANGPTL7 may activate signal transduction pathways that cannot be activated by SCF, TPO, IGF-2 or FGF-1. Human ANGPTL7, characterized as potent target gene of wnt/ beta-catenin signalling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine.
 
Technical Info/Product Notes:FLAG is a registered trademark of Sigma-Aldrich Co.
 
201-395
Figure: SDS-PAGE of ANGPTL7 (Fibrinogen-like Domain) (human) (rec.) (Prod. No. ALX-201-395).
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201-395

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