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COMP (rat):Angiopoietin-1 (human), (recombinant)

Soluble, stable and more potent Ang-1 variant.
 
ALX-201-314-C010 10 µg 504.00 USD
 
ALX-201-314-C050 50 µg 1,257.00 USD
 
ALX-201-314-C500 500 µg 5,304.00 USD
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Soluble, stable and more potent Ang-1 variant.

Product Specification

Alternative Name:COMP:Ang-1
 
Source:Produced in CHO cells. The fibrinogen-like domain (aa 284-498) of human Ang-1 (angiopoietin-1) is fused at the N-terminus to the coiled-coil domain of rat COMP (cartilage oligomeric matrix protein) and to a FLAG®-tag.
 
UniProt ID:Q15389 (human Angiopoietin-1), P35444 (rat COMP)
 
Concentration:~0.3mg/ml
 
Formulation:Liquid. 0.2µm-filtered solution in PBS containing 0.01% CHAPS.
 
Purity:≥90% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg protein (LAL test; BioWhittaker)
 
Specificity:Binds to human Tie-2.
 
Biological Activity:Induces phosphorylation of Tie-2 in primary cultured human and mouse vascular endothelial cells. More potent than native Ang-1.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:Working aliquots are stable for up to 3 months when stored at -80°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
 
Technical Info/Product Notes:FLAG is a registered trademark of Sigma-Aldrich Co.
 
201-314 1
Figure 1: COMP (rat):Angiopoietin-1 (human) (rec.) (Prod. No. ALX-201-314) forms mainly pentameric structures. Method: Glycerol spraying/low angle rotary metal-shadowed specimens were imaged by transmission electron microscopy.
201-314 2
Figure 2: COMP (rat):Angiopoietin-1 (human) (rec.) (Prod. No. ALX-201-314) induces phosphorylation of Tie-2 in human umbilical vein endothelial cells.Method: Serum-starved human umbilical vein endothelial cells were treated with 200ng/ml of BSA (Co) or 20ng/ml of COMP:Angiopoietin-1 for 15 min. The phosporylation of Tie-2 (phospho-Tie-2) was measured after immunoprecipitation.
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Product Literature References

Angiopoietin-1 deficiency increases tumor metastasis in mice: I.P. Michael, et al.; BMC Cancer 17, 539 (2017), Abstract; Full Text
Effects of Angiopoietin-1 on Hemorrhagic Transformation and Cerebral Edema after Tissue Plasminogen Activator Treatment for Ischemic Stroke in Rats: K. Kawamura, et al.; Plos One 9, e98639 (2014), Abstract; Full Text
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation: T. Morisada, et al.; Blood 105, 4649 (2005), Abstract;
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2: P. Saharinen, et al.; J. Cell Biol. 169, 239 (2005), Abstract;
COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity: C.H. Cho, et al.; PNAS 101, 5547 (2004), Abstract; Full Text
Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis: C.H. Cho, et al.; PNAS 101, 5553 (2004), Abstract; Full Text

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