Replaces Prod. #: BML-SE256
Product Details
| MW: | ~14.5kDa (MW in SDS-PAGE will be shifted up). |
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| Source: | Produced in E. coli. |
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| UniProt ID: | P37840 |
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| Concentration: | 1mg/ml. |
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| Formulation: | Liquid. In 20mM TRIS-HCl, pH 7.5, containing 0.1M sodium chloride and 1mM magnesium dichloride. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | <1.0EU/µg of protein (LAL method). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Avoid freeze/thaw cycles. |
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| Scientific Background: | α-synuclein is a major component of Parkinson’s disease aggregates and is implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders. α-synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson’s disease. α-synuclein appears to associate with other proteins that aggregate and is found in β-amyloid plaques and neuritic tangles in Alzheimer’s disease. |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: 14% SDS-PAGE of α-Synuclein (human) (rec.) (Prod. No.
ALX-201-265)."
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Product Literature References
Engineered graphene quantum dot nanocomposite triggers α-synuclein defibrillation: Therapeutics against Parkinson's disease: P. Kaliyaperumal, et al.; Nanomedicine
47, 102608 (2023),
Abstract;
Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators: D. Kempuraj, et al.; PLoS One
10, e0135776 (2015),
Application(s): Stimulating mouse and human mast cells to release IL-1β,
Abstract;
Full Text
General Literature References
Neurobiology of alpha-synuclein : K. Vekrellis, et al.; Mol. Neurobiol.
30, 1 (2004), (Review),
Abstract;
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease: E. Mashliah et al.; PNAS
98, 12245 (2001),
Abstract;
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid: K.A. Conway et al.; Biochemistry
39, 2552 (2000),
Abstract;
.: R. Jakes et al.; FEBS Lett.
345, 27 (1994),
Abstract;
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease: K. Ueda et al.; PNAS
90, 11282 (1993),
Abstract;
