Glycoprotein with a variety of functions. Important for exchange of lipids from CD1 molecules to lysosomal antigens.
Product Details
| Alternative Name: | Co-β-glucosidase, A1 activator, Glucosylceramidase activator, Sphingolipid activator protein 2, SAP-2 |
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| MW: | ~8kDa |
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| Source: | Produced in E. coli. Human recombinant saposin C (aa 309-388) is fused at the C-terminus to a His-tag and at the N-terminus to a T-7-tag. |
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| UniProt ID: | P07602 |
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| Formulation: | Lyophilized. In 50mM Tris, pH 6.0, containing 150mM sodium chloride. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | <0.1EU/µg purified protein (LAL test; Bio Whittaker). |
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| Reconstitution: | Reconstitute with 100µl sterile water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least one year after receipt when stored at +4°C. |
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| Regulatory Status: | RUO - Research Use Only |
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SDS-PAGE Analysis: Lane 1: MWM; Lane 2: 1.0 µg of purified Saposin C.
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Product Literature References
Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins: D. Zhou, et al.; Science
303, 523 (2004),
Abstract;
Saposin C is required for lipid presentation by human CD1b: F. Winau, et al.; Nat. Immunol.
5, 169 (2004),
Abstract;
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