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LAIR-1 (human) (22-125), (recombinant)

 
ALX-201-184-C100 100 µg 291.00 USD
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Product Specification

Alternative Name:Leukocyte-associated Ig-like receptor 1, CD305
 
MW:~11.7kDa.
 
Source:Produced in E. coli. Extracellular domain of human LAIR-1 (aa 22-125).
 
UniProt ID:Q6GTX8
 
Concentration:1mg/ml
 
Formulation:Liquid. In 20mM TRIS-HCl, pH 7.5, containing 50mM sodium chloride and 1mM EDTA.
 
Purity:≥95% (SDS-PAGE)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Avoid freeze/thaw cycles.
 
Scientific Background:LAIR-1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. It features of a leader sequence, extracellular domain, transmembrane domain and a cytoplasmic region.
 
201-184
Figure: 14% SDS-PAGE of human recombinant LAIR-1 (22-125) (Prod. No. ALX-201-184).
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201-184

General Literature References

Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells: J.G. Sathish, et al.; J. Immunol. 166, 1763 (2001), Abstract; Full Text
LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells: L. Meyaard; Curr. Top. Microbiol. Immunol. 244, 151 (1999), Abstract;
Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells: L. Meyaard, et al.; J. Immunol. 162, 5800 (1999), Abstract; Full Text
LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes: L. Meyaard, et al.; Immunity 7, 283 (1997), Abstract;

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