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Phosphoinositide 3-kinase p110α/p85 (bovine), (recombinant)

 
ALX-201-119-C005 5 µg 318.00 USD
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Product Specification

Alternative Name:PI(3)K p110α/p85
 
MW:p110α: ~124.3kDa; p85: ~83.5kDa.
 
Source:Produced in Sf9 cells. Bovine PI(3)K p110α/p85 dimer untagged.
 
UniProt ID:P32871 (p110α), P23727 (p85α), P23726 (p85β), O46404 (P85γ)
 
Concentration:0.1mg/ml
 
Formulation:Liquid. Recombinant protein in 25mM HEPES, pH 8.0, 25mM sodium chloride, 2.5mM magnesium dichloride and 50% glycerol.
 
Purity:≥90% (SDS-PAGE)
 
Specific Activity:~1nmol/mg/min using phosphatidyl-inositol as the substrate.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-20°C
 
Handling:Avoid freeze/thaw cycles.
 
Scientific Background:Phosphoinositide 3- kinases (PI(3)Ks) phosphorylate the 3'-OH position of inositol phospholipids. The heterodimeric complex consists of a catalytic subunit (p110α) and a regulatory adaptor subunit (p85). The PI(3)K regulates the MAP kinase and the Akt/PKB signalling pathway that is involved in pivotal cellular processes such as mitogenesis, apoptosis and cytoskeletal functions, and also plays an important role in the development of human cancer.
 

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