Product Details
| Alternative Name: | Poly(ADP-ribose) polymerase 2 |
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| Source: | Produced in Sf9 insect cells (full length). Produced in a baculovirus expression system. |
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| EC: | 2.4.2.30 |
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| UniProt ID: | O88554 |
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| Concentration: | ~1mg/ml |
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| Formulation: | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 1mM DTT, 0.5mM EDTA, 0.5mM PMSF and 20% glycerol. |
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| Purity: | ≥98% (SDS-PAGE) |
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| Purity Detail: | Affinity purified. |
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| Specific Activity: | ≥200U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1nmol of poly(ADP-ribose) per min at 25°C, pH 7.5. See also separate protocol (link below). |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Handling: | Avoid freeze/thaw cycles. |
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| Regulatory Status: | RUO - Research Use Only |
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Quality Control: 12% SDS-Polyacrylamide gel.
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Product Literature References
TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation: A. Tolić , et al.; Epigenetics Chromatin
15, 11 (2022),
Abstract;
Quantitative correlation between cellular proliferation and nuclear poly (ADP-ribose) polymerase (PARP-1): E. Kun, et al.; Int. J. Mol. Med.
17, 293 (2006),
Abstract;
Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing: M. Malanga & F.R. Althaus; J. Biol. Chem.
279, 5244 (2004),
Abstract;
Full Text
A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. structure and expression of the mouse PARP-2 gene: J.C. Ame, et al.; J. Biol. Chem.
276, 11092 (2001),
Abstract;
Full Text
PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase: J.C. Ame, et al.; J. Biol. Chem.
274, 17860 (1999),
Abstract;
Full Text
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