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PARP-1 (human), (recombinant) (high purity)

 
ALX-201-063-C020 20 µg 457.00 USD
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Product Specification

Alternative Name:Poly(ADP-ribose) polymerase 1
 
Source:Produced in Sf9 cells.
 
EC:2.4.2.30
 
UniProt ID:P09874
 
Concentration:1mg/ml
 
Formulation:Liquid. In 100mM TRIS-HCl, pH 7.5, containing 14mM β-mercaptoethanol, 0.5mM EDTA, 0.5mM PMSF and 10% glycerol.
 
Purity:≥99% (SDS-PAGE)
 
Purity Detail:Affinity purified.
 
Specific Activity:≥600U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1nmol of poly(ADP-ribose) per min. at 25°C, pH 7.5.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Handling:Avoid freeze/thaw cycles.
 
201-063
Quality Control: 10% SDS-Polyacrylamide gel.
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201-063

Product Literature References

Mapping PARP-1 auto-ADP-ribosylation sites by liquid chromatography-tandem mass spectrometry: J.D. Chapman, et al.; J. Proteome Res. 12, 1868 (2013), Abstract;
Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription: T. Wu, et al.; Free Radic. Biol. Med. 67C, 69 (2013), Abstract;
Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis: C. Leptrête, et al.; Int. J. Biochem. Cell Biol. 41, 1046 (2009), Abstract;
Poly(ADP-ribose) polymerase 1 binds to Pax8 and inhibits its transcriptional activity: T. Di Palma, et al.; J. Mol. Endocrinol. 41, 379 (2008), Abstract;
Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing: M. Malanga & F.R. Althaus; J. Biol. Chem. 279, 5244 (2004), Abstract; Full Text
Overproduction and large-scale purification of the human poly(ADP- ribose) polymerase using a baculovirus expression system: H. Giner, et al.; Gene 114, 279 (1992), Abstract;

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