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Myelin basic protein (human brain), (high purity)

 
ALX-200-606-M001 1 mg 466.00 USD
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Replaces Prod. #: BML-SE441

Product Specification

Alternative Name:MBP
 
MW:MBP contains 14.2kDa (13.0 minor) and 18.5kDa (17.2 minor) isoforms as well as their dimers (13.5% SDS-PAGE, non-reducing conditions).
 
Source:Purified from human brain.
 
UniProt ID:P02686
 
Concentration:1mg/ml after reconstitution.
 
Formulation:Lyophilized. No preservatives added.
 
Purity:≥95% (SDS-PAGE; Immunoblot)
 
Appearance:White to off-white powder.
 
Application Notes:Can be used to induce relapsing experimental autoimmune encephalomyelitis in animals. This product may also be used as a substrate for protein kinases. Suitable for use in ELISA or for antigen applications in immunological protocols. Immunoreactivity is verified using polyclonal and monoclonal antibodies against MBP.
 
Reconstitution:Reconstitute with 10mM HCl. Further dilutions can be made in assay buffer.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for 12 months at -20°C.
 
Scientific Background:MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca2+-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley. MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.
 

General Literature References

Interaction between the C-terminal region of human myelin basic protein and calmodulin: analysis of complex formation and solution structure: V. Majava, et al.; BMC Struct. Biol. 8, 10 (2008), Abstract; Full Text
Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997), Abstract;

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