Serum copper transport and iron-oxidizing protein. Expressed in plasma at concentrations of 1-5µM. Contains six copper centers and is known to oxidize amines in a process coupled to the reduction of molecular oxygen. Has ferroxidase activity that is responsible for the oxidation of ferrous iron to its ferric form, which is necessary for efficient iron efflux from the cell (e.g. during hypoxia). Has previously been considered a target for nitric oxide (NO) and an inhibitor of endothelial nitric oxide synthase (eNOS/NOS III). Catalyzes S-nitrosothiol formation in cell culture media. Is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis.
Product Details
Alternative Name: | Ferroxidase |
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MW: | ~134kDa |
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Source: | Isolated from human plasma. |
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EC: | 1.16.3.1 |
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CAS: | 9031-37-2 |
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MI: | 14: 2006 |
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UniProt ID: | P00450 |
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Formulation: | Lyophilized from 50mM potassium phosphate, pH 6.8, containing 100mM potassium chloride, 20mM ε-aminocaproic acid and 5mM EDTA. |
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Purity: | ≥95% (SDS-PAGE) |
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Purity Detail: | Plasma has been tested negative for HBsAg and for antibodies to HIV and HCV. |
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Reconstitution: | Reconstitute with distilled water. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients: S.M. Alverez-Fernandez, et al.; Oncotarget
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Ceruloplasmin functional changes in Parkinson’s disease-cerebrospinal fluid: M. Barbariga, et al.; Mol. Neurodegener.
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Application(s): Ceruloplasmin in CSFs and immunoprecipitation,
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Oxidation-induced structural changes of ceruloplasmin foster NGR-motifs deamidation that promote integrin binding and signalling: M. Barbariga, et al.; J. Biol. Chem.
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Application(s): Use in cell culture,
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Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis: A.J. Roth, et al.; J. Clin. Invest.
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Application(s): Control for mass spectrometry analysis,
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Full Text
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis: S. Shiva, et al.; Nat. Chem. Biol.
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