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Substance P

ALX-167-003-M001 1 mg 45.00 USD
ALX-167-003-M005 5 mg 156.00 USD
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Replaces Prod. #: BML-P501

Neuropeptide inducing Ca2+ mobilization. Activates G1-Proteins directly. Induces superoxide production in neutrophils.

Product Specification

MI:14: 8863
Purity:≥97% (HPLC)
Solubility:Soluble in DMSO or water.
Long Term Storage:-20°C
Scientific Background:Substance P (SP) was first discovered in 1931 by von Euler and Gaddum and is the best characterized member of the neurokinins. This class of peptide neurotransmitters includes neurokinin A (NK-A) and B (NK-B), and are characterized by the common C-terminal sequence Phe-X-Gly-Leu-Met-NH2. The receptors for SP, NK-A and NK-B, designated NK1, NK2 and NK3 respectively, are members of the G protein-coupled receptor superfamily. All three receptors have been shown to stimulate inositol phospholipid hydrolysis. SP is involved in pain, smooth muscle contraction, secretion from exocrine and endocrine glands, inflammatory response including vasodilation, plasma extravasation and mobilization of immune system cells.

Product Literature References

Intracellular signaling pathway of substance P-induced superoxide production in human neutrophils: T. Tanabe, et al.; Eur. J. Pharmacol. 299, 187 (1996), Abstract;
Sera from patients with falciparum malaria induce substance P gene expression in cultured human brain microvascular endothelial cells: C.B. Chiwakata, et al.; Infect. Immun. 64, 5106 (1996), Abstract;
Neuropeptide Y promotes GTP photo-incorporation into a 55 kDa protein: J. Zhu, et al.; Eur. J. Pharmacol. 268, 279 (1994), Abstract;
Substance P elevates intracellular calcium in both neurons and glial cells from the dorsal horn of the spinal cord: M.J. Heath, et al.; J. Neurophysiol. 72, 1192 (1994), Abstract;
Human lymphocytes lack substance P receptors: A. I. Roberts et al.; Cell. Immunol. 141, 457 (1992), Abstract;

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