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Sarafotoxin S6c

Endothelin receptor activator
ALX-167-002-PC01 0.1 mg* 102.00 USD
ALX-167-002-PC05 0.5 mg* 326.00 USD
Do you need bulk/larger quantities?
Potent vasoconstrictor peptide. Causes hydrolysis of phosphoinositides in atrial and brain membranes.

Product Specification

Sequence:H-Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH (Disulfide bonds between Cys1-Cys15 and Cys3-Cys11)
Source:Synthetic. Originally isolated from Atractaspis engaddensis.
Quantity:*Sold as net peptide weight.
Appearance:White lyophilized powder.
Solubility:Soluble in 5% acetic acid.
Long Term Storage:-20°C

Product Literature References

Simultaneous changes in intracellular calcium and tension induced by endothelin-1 and sarafotoxin S6c in guinea pig isolated gallbladder: influence of indomethacin: A.M. Cardozo, et al.; Can. J. Physiol. Pharmacol. 80, 458 (2002), Abstract;
Endothelium-dependent modulation of venoconstriction to sarafotoxin S6c in human veins in vivo: F.E. Strachan, et al.; J. Cardiovasc. Pharmacol. 26 Suppl. 3, S180 (1995), Abstract;
Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes: D.L. Williams, Jr., et al.; Biochem. Biophys. Res. Commun. 175, 556 (1991), Abstract;
Sarafotoxin S6c is a relatively weak displacer of specifically bound 125I-endothelin: W.G. Nayler, et al.; Biochem. Biophys. Res. Commun. 161, 89 (1989), Abstract;
Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart: C. Takasaki, et al.; Toxicon 26, 543 (1988), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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