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PHC-SKKKK . 3 TFA

Negative control for Pam3Cys-Ser-(Lys)4 . trihydrochloride
 
ALX-165-071-M001 1 mg 373.00 USD
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Does not activate TLR2. Can be used as negative control for Pam3Cys-Ser-(Lys)4 . trihydrochloride (Prod. No. ALX-165-066).

Product Specification

Alternative Name:PHCSK4 . 3 TFA, N-palmitoyl-S-(1,2-bishexadecyloxy-carbonyl)-ethyl-(R)-cysteinyl-seryl-(lysyl)3-lysine . 3 CF3COOH
 
Formula:C82H158N10O13S . 3 CF3COOH
 
MW:1524.3 . 342.1
 
Source:Synthetic
 
Concentration:1mg/ml after reconstitution.
 
Formulation:Lyophilized.
 
Quality Control:Confirmed by ESI-MS.
 
Appearance:Colorless powder
 
Solubility:Soluble in pyrogen-free deionized water, DMSO or aqueous buffers at pH <7.5
 
Reconstitution:Reconstitute with 2 mL pyrogen-free deionized water in a pyrogen-free tube. Reconstitution can also be performed in DMSO (1mg/ml stock solution). Homogenize by vortexing or use a homogenizer or sonicator to prepare a homogenous solution. Further dilutions can be made with cell culture medium or pyrogen-free deionized water. PBS is not recommended for reconstitution or dilution.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Scientific Background:Lipopeptides are valuable tools for basic research in innate and acquired immunity. PHC-SKKKK (PHC-SK4) and Pam3Cys-SKKKK (P3SK4) (Prod. No. ALX-165-066) have similar physicochemical properties, both have three fatty acid residues and the same peptide moiety. In contrast to P3SK4, PHCSK4 is not an activator of TLR2.
 
ALX-165-071 structure
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ALX-165-071 structure

Product Literature References

The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation: D.T. Nguyen, et al.; PLoS Pathog. 6, e1001049 (2010), Abstract;
Synthetic bacterial lipopeptide analogs: structural requirements for adjuvanticity: M. Ghielmetti, et al.; Immunobiology 210, 211 (2005), Abstract;
Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes: G. Meng, et al.; J. Clin. Invest. 113, 1473 (2004), Abstract;
The ester-bonded palmitoyl side chains of Pam3CysSerLys4 lipopeptide account for its powerful adjuvanticity to HLA class I-restricted CD8+ T lymphocytes: A. Reschner, et al.; Eur. J. Immunol. 33, 2044 (2003), Abstract;

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