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Pam3Cys-Ser-(Lys)4 (Aca-Aca-Biotin) . 2 trifluoroacetate

Selective agonist of TLR1/TLR2 complex
 
ALX-165-069-M001 1 mg 1,625.00 USD
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Selective, biotin-labelled ligand of Toll-like receptor 1 (TLR1) complexed with TLR2. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Activates/represses an array of at least 140 genes partly involved in signal transduction and regulation of the immune response.

Product Specification

Alternative Name:Pam3CSK4 (Aca-Aca-Biotin) . 2TFA, (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH Aca-Aca-Biotin) . 2TFA
 
Formula:C103H192N14O17S2 . 2C2HF3O2
 
MW:1962.9 . 228.1
 
Formulation:Lyophilized.
 
Quality Control:Confirmed by ESI-MS.
 
Appearance:Colorless powder.
 
Solubility:Soluble in water, saline or aqueous buffers at pH <7.5.
 
Reconstitution:Reconstitute with water to 1mg/ml stock solution. Through the use of either a homogeniser or sonicator, a homogenous solution can be prepared.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
ALX-165-069 structure
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ALX-165-069 structure

Product Literature References

Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases: E.G. Stefanich, et al.; Biochem. Pharmacol. 152, 224 (2018), Abstract;
The role and regulation of Moraxella catarrhalis-induced human beta-defensin 3 expression in human pulmonary epithelial cells: H. Haarmann, et al.; Biochem. Biophys. Res. Commun. 467, 46 (2015), Application(s): Cell Culture, Abstract;

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Selective agonist of TLR1/TLR2 complex
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