Selective agonist of Toll-like receptor 1 (TLR1) complexed with TLR2. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Activates/represses an array of at least 140 genes partly involved in signal transduction and regulation of the immune response.
Product Details
Alternative Name: | Pam3CSK4 . 3HCl, (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH . 3HCl, Pam3Cys-SKKKK |
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Formula: | C81H156N10O13S . 3HCl |
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MW: | 1510.3 . 109.4 |
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CAS: | 112208-00-1 |
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Concentration: | 1mg/ml after reconstitution. |
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Formulation: | Lyophilized. |
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Quality Control: | Confirmed by ESI-MS. |
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Solubility: | Soluble in pyrogen-free deionized water, DMSO or aqueous buffers at pH <7.5. |
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Reconstitution: |
Reconstitute with 2 ml pyrogen-free deionized water in a pyrogen-free tube. Reconstitution can also be performed in DMSO (1mg/ml stock solution). Homogenize by vortexing or use a homogenizer or sonicator to prepare a homogenous solution. Further dilutions can be made with cell culture medium or pyrogen-free deionized water. PBS is not recommended for reconstitution or dilution. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
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Technical Info/Product Notes: | For negative control see Prod. No. ALX-165-071 |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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