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Obestatin (mouse, rat)

Food intake modulator
 
ALX-164-005-M001 1 mg 160.00 USD
 
ALX-164-005-M005 5 mg 598.00 USD
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Obestatin derives like ghrelin from proghrelin, but exhibits opposite physiological effects. Obestatin decreases food intake and body weight in rodents. Moreover, obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility. Obestatin binds to orphan G protein-coupled receptor GPR39. Amidation of the C-terminus seems to be important for obestatin’s activity.

Product Specification

Sequence:H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2
 
Formula:C114H174N34O31
 
MW:2516.8
 
Formulation:Lyophilized.
 
Peptide Content:≥80%
 
Purity:≥97% (HPLC)
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

Obestatin inhibits dopamine release in rat hypothalamus: L. Brunetti, et al; Eur. J. Pharmacol. 641, 142 (2010), Abstract;
Biomedicine. Separation of conjoined hormones yields appetite rivals: R. Nogueiras & M. Tschop; Science 310, 985 (2005), (Comment), Abstract;
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake: J.V. Zhang, et al.; Science 310, 996 (2005), Abstract;

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