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NBD peptide / NF-κB blocker (cell permeable)

 
ALX-163-011-1 1 Vial 274.00 USD
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For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.

Product Specification

Alternative Name:NEMO-binding domain peptide
 
Sequence:GRKKRRQRRR-GG-TALDWSWLQTE-amide
 
Formula:C121H202N48O32
 
MW:2841.2
 
Quantity:50µl
 
Concentration:10mM
 
Formulation:Liquid. In sterile PBS.
 
Purity:≥95% (HPLC)
 
Shipping:Shipped on Dry Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-80°C
 
Handling:Keep on ice at all times. Protect from moisture. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
 

Product Literature References

CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury: H. Akahori, et al.; Nat. Commun. 6, 7792 (2015), Application(s): Intraperitoneal administration in mice, Abstract;
Disruption of IKK-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to HDAC inhibitors: Y. Dai, et al.; J. Biol. Chem. 286, 34036 (2011), Abstract;
Improvement of cardiac contractile function by peptide-based inhibition of NF-kappaB in the utrophin/dystrophin-deficient murine model of muscular dystrophy: D.A. Delfin, et al.; J. Transl. Med. 9, 68 (2011), Abstract; Full Text
Selective inhibition of NF-kappaB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo: E. Jimi, et al.; Nature Med. 10, 617 (2004), Abstract;
Characterization of the Ikappa B-kinase NEMO binding domain: M.J. May, et al.; J. Biol. Chem. 277, 45992 (2002), Abstract;
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex: M.J. May, et al.; Science 289, 1550 (2000), Abstract;

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