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Melittin (natural)

PLA2 activator
 
ALX-162-006-M001 1 mg 61.00 USD
 
ALX-162-006-M005 5 mg 230.00 USD
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Causes disruption of normal cellular activity and cell lysis. Binds calmodulin in a calcium-dependent manner. Activates phospholipase A2 (PLA2) and inhibits protein kinase C (PKC) by binding to the catalytic domain in a Mg-ATP sensitive manner. Antirheumatic.

Product Specification

Sequence:H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
 
Formula:C131H229N39O31
 
MW:2846.5
 
Source:Isolated from bee venom.
 
CAS:37231-28-0
 
MI:14: 5824
 
RTECS:OS3960000
 
Purity:≥85% (HPLC)
 
Purity Detail:Phospholipase A2 impurity: <5 units per mg solid.
 
Appearance:White to faint tan powder.
 
Solubility:Soluble in PBS (5mg/ml) or water (5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Very hygroscopic. Protect from light.
 
162-006
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162-006

Product Literature References

Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-kappaB: M.H. Park, et al.; Prostate 71, 801 (2011), Abstract;
Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells: S.T. Chu, et al.; Life Sci. 80, 364 (2007), Abstract;
Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds: D.J. Son, et al.; Pharmacol. Ther. 115, 246 (2007), Abstract;
Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression: M. Wachinger, et al.; J. Gen. Virol. 79, 731 (1998), Abstract;
Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo: C.L. Ownby, et al.; Toxicon. 35, 67 (1997), Abstract;
Melittin binds to secretory phospholipase A2 and inhibits its enzymatic activity: S.S. Saini, et al.; BBRC 238, 436 (1997), Abstract;
Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin: J.E. Fletcher & M.S. Jiang; Toxicon. 31, 669 (1993), Abstract;
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C: J. Baudier, et al.; Biochemistry 26, 2886 (1987), Abstract;
Rapid purification of calmodulin and S-100 protein by affinity chromatography with melittin immobilized to sepharose: R.L. Kincaid & C.C. Coulson; BBRC 133, 256 (1985), Abstract;

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