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MCD peptide

Potent anti-inflammatory agent and immunomodulator
 
ALX-162-002-MC05 0.5 mg 281.00 USD
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Potent anti-inflammatory agent and strong mediator of mast cell degranulation and histamine release. Neurotoxin and voltage-dependent K+ channel blocker. Inhibits the ADP-ribosylation of the small GTP-binding proteins rho.

Product Specification

Alternative Name:Mast cell degranulating peptide
 
Sequence:H-Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2
(Disulfide bonds between Cys3-Cys15 and Cys5-Cys19)
 
Formula:C110H192N40O24S4
 
MW:2587.2
 
Source:Synthetic. Originally isolated from Apis mellifera.
 
CAS:83856-13-7
 
Purity:≥98%
 
Appearance:Lyophilized.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80: G. Koch, et al.; Eur. J. Pharmacol. 226, 87 (1992), Abstract;
Mast cell degranulating peptide: a multi-functional neurotoxin: M.R. Ziai, et al.; J. Pharm. Pharmacol. 42, 457 (1990), Review, Abstract;
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990), Abstract;
Bee and wasp venoms: E. Haberman; Science 177, 314 (1972), Abstract;

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