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Humanin (human)

Bax inhibitor
 
ALX-158-011-MC05 0.5 mg 164.00 USD
 
ALX-158-011-M001 1 mg 274.00 USD
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Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer's disease and by amyloid-β protein. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin. Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro.

Product Specification

Sequence:H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
 
Formula:C119H204N34O32S2
 
MW:2687.3
 
CAS:330936-69-1
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO or 5% acetic acid.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

Humanin peptide suppresses apoptosis by interfering with Bax activation: B. Guo, et al.; Nature 423, 456 (2003), Abstract;
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta: Y. Hashimoto, et al.; PNAS 98, 6336 (2001), Abstract; Full Text
Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults: Y. Hashimoto, et al.; J. Neurosci. 21, 9235 (2001), Abstract; Full Text
Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein: Y. Hashimoto, et al.; BBRC 283, 460 (2001), Abstract;

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