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Ghrelin (rat)

Endogenous GHS-R ligand
 
ALX-157-022-MC05 0.5 mg 189.00 USD
 
ALX-157-022-M001 1 mg 316.00 USD
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Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on th cardiovascular and immune system.

Product Specification

Sequence:H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
 
Formula:C147H244N45O42
 
MW:3313.8
 
CAS:258338-12-4
 
Formulation:Lyophilized.
 
Purity:≥98% (HPLC)
 
Solubility:Soluble in H2O or 5% acetic acid.
 
Reconstitution:Reconstitute by adding 100 ul H2O to 1 mg of Ghrelin peptide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Obestatin inhibits dopamine release in rat hypothalamus: L. Brunetti, et al; Eur. J. Pharmacol. 641, 142 (2010), Abstract;
Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect: C.X. Huang, et al.; Peptides 30, 2286 (2009), Abstract; Full Text
(Ghrelin and immunity: a young player in an old field: V.D. Dixit & D.D. Taub; Exp. Gerontol. 40, 900 (2005), (Review), Abstract;
Developments in ghrelin biology and potential clinical relevance: R.G. Smith, et al.; Trends Endocrinol. Metab. 16, 436 (2005), (Review), Abstract;
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review), Abstract;
Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation: C. Dieguez & F.F. Casanueva; Eur. J. Endocrinol. 142, 413 (2000), Abstract; Full Text
Ghrelin is a growth-hormone-releasing acylated peptide from stomach: M. Kojima, et al.; Nature 402, 656 (1999), Abstract;

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