ET_B receptor antagonist [RES-701-1]



ALX-155-018-MC05	0.5 mg	85.00 USD

ALX-155-018-M001	1 mg	130.00 USD

Inhibits selectively the ET-1 binding to the ET_B receptor.

Product Specification

Formula:	C₁₀₃H₁₁₅N₂₃O₂₃

MW:	2043.2

Purity:	≥97% (HPLC)

Sequence:	Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp-OH (Beta peptide bond between Gly¹and Asp⁹).

Formulation:	Lyophilized.

Peptide Content:	75-90%

Solubility:	Soluble in DMSO (5mg/ml); dilute with 0.6ml distilled water.

Long Term Storage:	-20°C

Product Literature References

J.X. He, et al.; Bioorg. Med. Chem. Lett. 5, 621 (1995),

RES-701-1, a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. RE-701. I. Characterization of producing strain, fermentation, isolation, physico-chemical and biological properties: Y. Morishita, et al.; J. Antibiot. 47, 269 (1994), Abstract;

Subtypes of endothelin ETA and ETB receptors mediating venous smooth muscle contraction: S.A. Sudjarwo, et al.; BBRC 200, 627 (1994), Abstract;