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United States 

ET receptor antagonist [PD 142,893]

 
ALX-155-008-PC05 0.5 mg* 87.00 USD
 
ALX-155-008-P001 1 mg* 128.00 USD
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Non-selective antagonist of endothelin-1 with high affinity for both the ETA and ETB receptor subtypes.

Product Specification

Sequence:Ac-D-Dip-Leu-Asp-Ile-Ile-Trp-OH (D-Dip = D-3,3-Diphenylalanine; Lit. THL 33, 3293 (1992))
 
Formula:C50H65N7O10
 
MW:924.1
 
Quantity:*Sold as net peptide weight.
 
Purity:≥97% (HPLC)
 
Appearance:White lyophilized powder.
 
Solubility:Soluble in a mixture of 10% acetonitrile and 90% water or in phosphate buffer, pH 7.5.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

Endothelin: progress in pharmacology and physiology: W.G. Haynes, et al.; TIPS 14, 225 (1993), (Review), Abstract;
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists: A.M. Doherty, et al.; J. Med. Chem. 36, 2585 (1993), Abstract;
Design of a functional hexapeptide antagonist of endothelin: W.L. Cody, et al.; J. Med. Chem. 35, 3301 (1992), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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