United States
ET receptor antagonist [PD 142,893]
| ALX-155-008-PC05 | 0.5 mg* | 62.00 USD |  |
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| ALX-155-008-P001 | 1 mg* | 95.00 USD | |
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Non-selective antagonist of endothelin-1 with high affinity for both the ETA and ETB receptor subtypes.
Product Specification
| Formula: | C50H65N7O10 |
| MW: | 924.1 |
| Quantity: | *Sold as net peptide weight. |
| Purity: | ≥97% |
| Appearance: | White lyophilized powder. |
| Sequence: | Ac-D-Dip-Leu-Asp-Ile-Ile-Trp-OH (D-Dip = D-3,3-Diphenylalanine; Lit. THL 33, 3293 (1992)) |
| Solubility: | Soluble in a mixture of 10% acetonitrile and 90% water or in phosphate buffer, pH 7.5. |
| Long Term Storage: | -20°C |
Product Literature References
Endothelin: progress in pharmacology and physiology: W.G. Haynes, et al.; TIPS 14, 225 (1993), (Review), Abstract;
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists: A.M. Doherty, et al.; J. Med. Chem. 36, 2585 (1993), Abstract;
Design of a functional hexapeptide antagonist of endothelin: W.L. Cody, et al.; J. Med. Chem. 35, 3301 (1992), Abstract;
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