ET_B receptor antagonist [IRL-1038]



ALX-155-007-PC05	0.5 mg*	72.00 USD

ALX-155-007-P001	1 mg*	146.00 USD

Antagonist for the ET_Breceptor with a controversial pattern of activity.

Product Specification

Alternative Name:	[Cys¹¹-Cys¹⁵]-Endothelin-1 (11-21)

Formula:	C₆₈H₉₂N₁₄O₁₅S₂

MW:	1409.7

Quantity:	*Sold as net peptide weight.

Purity:	≥97%

Sequence:	H-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bonds between Cys¹-Cys⁵)

Long Term Storage:	-20°C

Product Literature References

An endothelin B receptor-selective antagonist: IRL 1038, [Cys11- Cys15]- endothelin-1(11-21): Y. Urade, et al.; FEBS Lett. 342, 103 (1994), Abstract;

Endothelin: progress in pharmacology and physiology: W.G. Haynes, et al.; TIPS 14, 225 (1993), (Review), Abstract;

A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor: M. Takai, et al.; BBRC 184, 953 (1992), Abstract;

An endothelin B receptor-selective antagonist: IRL 1038, [Cys11-Cys15]- endothelin-1(11-21) [retracted in: FEBS Lett 1994 Mar 28;342(1):103]: Y. Urade, et al.; FEBS Lett. 311, 12 (1992), Abstract;