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ETA receptor antagonist [BQ-123] . sodium salt

ALX-155-004-P001 1 mg* 137.00 USD
ALX-155-004-P005 5 mg* 457.00 USD
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Highly potent and selective ETA antagonist.

Product Specification

Sequence:cyclo(D-Asp-Pro-D-Val-Leu-D-Trp . Na)
Formula:C31H42N6O7 . Na
Quantity:*Sold as net peptide weight.
Solubility:Soluble in water.
Long Term Storage:-20°C
Use/Stability:Stable for at least 3 years after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
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Product Literature References

Endothelin: progress in pharmacology and physiology: W.G. Haynes, et al.; TIPS 14, 225 (1993), (Review), Abstract;
A novel ETA antagonist (BQ-123) inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis in rat vascular smooth muscle cells: S. Eguchi, et al.; FEBS Lett. 302, 243 (1992), Abstract;
Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor: M. Ihara, et al.; Life Sci. 50, 247 (1992), Abstract;
Conformational study of cyclo[D-Trp-D-Asp-Pro-D-Val-Leu], an endothelin- A receptor-selective antagonist: R.A. Atkinson & J.T. Pelton; FEBS Lett. 296, 1 (1992), Abstract;
Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications: K. Ishikawa, et al.; J. Med. Chem. 35, 2139 (1992), Abstract;
Identification of a domain of ETA receptor required for ligand binding: M. Adachi, et al.; FEBS Lett. 311, 179 (1992), Abstract;

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