Big Endothelin-1 (human) (1-38)

Endothelin-converting enzyme substrate



ALX-152-001-PC01	0.1 mg*	95.00 USD

ALX-152-001-PC05	0.5 mg*	412.00 USD

ALX-152-001-P001	1 mg*	670.00 USD

Biological precursor of endothelin 1. Cleaved to yield endothelin-1 via the activity of the endothelin-converting enzyme (ECE). Endothelins are endothelium-derived vasoconstrictor peptides.

Product Specification

Alternative Name:	Big ET-1 (1-38)

Formula:	C₁₈₉H₂₈₂N₄₈O₅₆S₅

MW:	4283.0

Quantity:	*Sold as net peptide weight.

Purity:	≥98% (HPLC)

Appearance:	White to off-white powder.

Sequence:	H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH (Disulfide bonds between Cys¹-Cys¹⁵and Cys³-Cys¹¹)

CAS:	121014-53-7

Solubility:	1mg/ml soluble in water; also soluble in 0.5% acetic acid.

Long Term Storage:	-20°C

Product Literature References

Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo: T. Kashiwabara, et al.; FEBS Lett. 247, 73 (1989), Abstract;

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988), Abstract;