Apamin

K⁺ channel blocker



ALX-151-013-MC05	0.5 mg	104.00 USD

Replaces Prod. #: BML-KC150

Originally isolated from Apis mellifera. A small conductance Ca²⁺-activated K⁺ channel blocker.

Product Specification

Formula:	C₁₃₁H₁₃₁N₃₁O₂₄S₄

MW:	2027.3

Purity:	≥93% (HPLC)

Appearance:	Lyophilized.

Sequence:	H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH₂ (Disulfide bonds between Cys¹-Cys¹¹and Cys³-Cys¹⁵)

CAS:	24345-16-2

MI:	14: 725

RTECS:	CD6899900

Source/Host:	Synthetic.

Solubility:	Soluble in 0.05M acetic acid (5mg/ml); slightly soluble in water (1mg/ml).

Long Term Storage:	-20°C

Hazard:	VERY TOXIC.

Product Literature References

GnRH-induced Ca2+ oscillations and rhythmic hyperpolarizations of pituitary gonadotropes.: A. Tse et al.; Science 255, 462 (1992), Abstract;

Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990), Abstract;

Toxins in the characterization of potassium channels: N.A. Castle, et al.; TINS 12, 59 (1989), (Review), Abstract;

Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle.: A.L. Blatz & K. L. Magleby; Nature 323, 718 (1986), Abstract;

Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor.: M. Hugues et al.; PNAS 79, 1308 (1982), Abstract;