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Apamin

K+ channel blocker
 
ALX-151-013-MC05 0.5 mg 123.00 USD
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Replaces Prod. #: BML-KC150

Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker.

Product Specification

Sequence:H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
(Disulfide bonds between Cys1-Cys11and Cys3-Cys15)
 
Formula:C79H131N31O24S4
 
MW:2027.3
 
Source:Synthetic.
 
CAS:24345-16-2
 
MI:14: 725
 
RTECS:CD6899900
 
Purity:≥95% (HPLC)
 
Appearance:Lyophilized.
 
Solubility:Soluble in 0.05M acetic acid (5mg/ml); slightly soluble in water (1mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

GnRH-induced Ca2+ oscillations and rhythmic hyperpolarizations of pituitary gonadotropes.: A. Tse et al.; Science 255, 462 (1992), Abstract;
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990), Abstract;
Toxins in the characterization of potassium channels: N.A. Castle, et al.; TINS 12, 59 (1989), (Review), Abstract;
Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle.: A.L. Blatz & K. L. Magleby; Nature 323, 718 (1986), Abstract;
Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor.: M. Hugues et al.; PNAS 79, 1308 (1982), Abstract;

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